The Remission Rate of Type 2 Diabetes Outpatients with Premixed
                    Insulin: The Result of a 5-Year Prospective Study

Fu-peng Liu; Ming-hui Sun; Jun-yu Zhao; Ming Yang; Xiao-jun Zhou; Zhong-wen Zhang; Jian-jun Dong; Lin Liao

doi:10.1055/a-1128-6957

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2020; 52(05): 316-321
DOI: 10.1055/a-1128-6957

Endocrine Care

The Remission Rate of Type 2 Diabetes Outpatients with Premixed Insulin: The Result of a 5-Year Prospective Study

Fu-peng Liu ‡

¹Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China

,

Ming-hui Sun‡

²Division of Endocrinology, Department of Internal Medicine, Liaocheng People’s Hospital, Liaocheng, China

,

Jun-yu Zhao

³Division of Endocrinology, Department of Internal Medicine, the First Affiliated Hospital of Shandong First Medical University, Jinan, China

⁴Division of Endocrinology, Department of Internal Medicine, Shandong Provincial, Qianfoshan Hospital, Shandong University, Jinan, China

,

Ming Yang

⁵Department of Internal Medicine, Peking University People’s Hospital, Peking, China

,

Xiao-jun Zhou

³Division of Endocrinology, Department of Internal Medicine, the First Affiliated Hospital of Shandong First Medical University, Jinan, China

⁴Division of Endocrinology, Department of Internal Medicine, Shandong Provincial, Qianfoshan Hospital, Shandong University, Jinan, China

,

Zhong-wen Zhang

³Division of Endocrinology, Department of Internal Medicine, the First Affiliated Hospital of Shandong First Medical University, Jinan, China

⁴Division of Endocrinology, Department of Internal Medicine, Shandong Provincial, Qianfoshan Hospital, Shandong University, Jinan, China

,

Jian-jun Dong

⁶Division of Endocrinology, Department of Medicine, Qilu Hospital of Jinan, Jinan, China

,

Lin Liao

³Division of Endocrinology, Department of Internal Medicine, the First Affiliated Hospital of Shandong First Medical University, Jinan, China

⁴Division of Endocrinology, Department of Internal Medicine, Shandong Provincial, Qianfoshan Hospital, Shandong University, Jinan, China

› Author Affiliations

Abstract

The aim of the study was to evaluate the remission rate with short-term premixed insulin therapy in newly diagnosed type 2 diabetes outpatients and investigate predictors contributing to the remission rate. A 5-year prospective study was conducted with a total of 170 patients enrolled. Patients were treated with premixed insulin monotherapy or insulin in combination with one or two oral drugs. After glucose levels were well controlled, insulin and oral drugs were discontinued in a stepwise manner. The prolonged and partial remission rates were calculated and the possible factors contributing to remission were also analyzed. A total of 164 subjects completed the research study. The prolonged remission, partial remission and non-remission rates at the 5-year follow-up were 9.8, 59.8, and 30.5%, respectively. The remission rate was negatively correlated with disease duration (r=0.39). The combined rate of remission (prolonged and partial remission) significantly decreased when the duration was longer than 16 days, and reduced to approximately 50% after 1 month. Moreover, 75% of prolonged remission patients had duration of < 16 days. At the 5-year follow-up, the prolonged remission rate was 9.8% and the partial remission rate was 59.8%. Furthermore, the duration after diagnosis is an independent predictor of remission rate, and initiation of short-term premixed insulin therapy within the first 16 days of diabetes diagnosis is very important for remission. This is the first study to evaluate the remission rate associated with short-term premixed insulin therapy in recently diagnosed type 2 diabetes outpatients. At the 5-year follow-up, the prolonged remission rate was 9.8% and the partial remission rate was 59.8%. The duration of diabetes was identified as an independent predictor of drug-free remission. The initiation of short-term premixed insulin therapy within 15 days of diabetes onset is particular importance for remission.

Key words

type 2 diabetes - outpatients - short-term premixed insulin therapy - remission rates - prospective study

Full Text

References

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